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KMID : 0354719940180040337
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Journal of Korean Diabetes Association
1994 Volume.18 No. 4 p.337 ~ p.343
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The Activity of Erythrocyte Antioxidant Enzymes According to Glucose Concentration in Non Insulin Dependent Diabetes Mellitus
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조희충
김미자/서정철/조영화/안기완/정종훈/박찬국/이승일/배학연
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Abstract
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Background:
@EN The concept that free radicals play a significant role in the pathogenesis of diabetes is becoming increasingly recognized. Diabetes represents a state of increased oxidative stress. Decreased antioxidant enzyme activity contributes to
oxidative
stress. The aim of the present study was to access the relationship between hyperglycemia and antioxidant enzyme activity.
@ES Methods :
@EN The antioxidant status of orythrocytes were studied in non insulin dependent diabetes mellitus and normal control group according to different glucose concentrations(5.6, 11.1, 22.2mmol/L) by measuring the activities of cellular antioxidant
enzymes(SOD, catalase). Antioxidant enzyme activity was measured at 3rd, 7th, 14th and 21st day of incubation.
@ES Results:
@EN 1) The superoxide dismutase activity of erythrocytes indiabetecs(25.1±0.11/㎎ Hb) was significantly lower than that in normal control(2.88±0.12U/㎎ Hb)(p<0.01).
2) The superoxide dismutase activity of erythrocyte in the normal control group did not decrease in the early period of incubation. But from the third day of incubation, the SOD activity decreased according to time course. The activity of SOD
was
significantly lower especially in high concentrations of glucose(22.2mmol/L) than in low concentrations of glucose(5.6mmol/L)(p<0.01).
3) The superoxide dismutase activity of erythrocyte in diabetics decreased from the third of incubation according to time course and was significantly lower in high concentrations of glucose(22.2mmol/L) than in low concentrations of
glucose(5.6mmol/L)(P<0.05).
4) The catalase activity of erythrocytes in the normal control group and diabetics decreased according to time course and was not significantly different in each glucose concentration.
@ES Conclusion:
@EN These results suggest that hyperglycemia may be an important factor for decreased SOD activity and it may be concluded that glucose control in diabetic patients may decreased the change of SOD activity and tissue damage due to oxidative
stress.
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KEYWORD
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